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建立新生鼠缺氧缺血性脑病（HIE）的模型，观察了大脑皮质超氧化物歧化酶（SOD）、丙二醛（MDA）、血清MDA和脑组织神经病理变化以及硫酸镁、川芎嗪对其影响。发现HIE组大脑皮质SOD、MDA和血清MDA升高明显，神经细胞变性显著。硫酸镁和川芎嗪能使大脑皮质SOD、MDA和血清MDA降低，神经细胞变性减轻。提示氧自由基在缺氧缺血性脑损害发病中的影响和硫酸镁、川芎嗪通过间接抗氧化作用对HIE的预防作用。
The model of hypoxic-ischemic encephalopathy (HIE) in neonatal rats was established. The changes of neuropathological changes of cerebral cortex such as superoxide dismutase (SOD), malondialdehyde (MDA), serum MDA and brain tissue were observed, and the effects of magnesium sulfate and ligustrazine Its impact. Found that HIE group cerebral cortex SOD, MDA and serum MDA increased significantly, significant degeneration of nerve cells. Magnesium sulfate and ligustrazine can make cerebral cortex SOD, MDA and serum MDA decreased, degeneration of nerve cells reduced. Prompted oxygen free radicals in the pathogenesis of hypoxic-ischemic brain damage and magnesium sulfate, ligustrazine through indirect antioxidant effect on the prevention of HIE.