【摘 要】
：
Transgenic mice carrying mutations that cause Autism Spectrum Disorders (ASDs) continue to be valuable for determining the molecular underpinnings of the disorders.Recently,researchers have taken advantage of such models combined with Cre-loxP and similar
【机 构】
：
Department of Neurobiology, School of Medicine, Duke University, Durham, NC 27710, USA
论文部分内容阅读
Transgenic mice carrying mutations that cause Autism Spectrum Disorders (ASDs) continue to be valuable for determining the molecular underpinnings of the disorders.Recently,researchers have taken advantage of such models combined with Cre-loxP and similar systems to manipulate gene expression over space and time.Thus,a clearer picture is starting to emerge of the cell types,circuits,brain regions,and developmental time periods underlying ASDs.ASD-causing mutations have been restricted to or rescued specifically in excitatory or inhibitory neurons,different neurotransmitter systems,and cells specific to the forebrain or cerebellum.In addition,mutations have been induced or corrected in adult mice,providing some evidence for the plasticity and reversibility of core ASD symptoms.The limited availability of Cre lines that are highly specific to certain cell types or time periods provides a challenge to determining the cellular and circuitry bases of autism,but other technological advances may eventually overcome this obstacle.
其他文献
Peripheral itch stimuli are transmitted by sensory neurons to the spinal cord dorsal horn,which then transmits the information to the brain.The molecular and cellular mechanisms within the dorsal horn for itch transmission have only been investigated and
Different physical and chemical stimuli are detected by the peripheral sensory receptors of dorsal root ganglion (DRG) neurons,and the generated inputs are transmitted via afferent fibers into the central nervous system.The gene expression profiles of DRG
Exploring the transition from inter-ictal to ictal epileptiform discharges (IDs) and how GABAA receptormediated action affects the onset of IDs will enrich our understanding of epileptogenesis and epilepsy treatment.We used Mg2+-free artificial cerebrospi
Chromosome microarray analysis (CMA) is a cost-effective molecular cytogenetic technique that has been used as a first-line diagnostic test in neurodevelopmental disorders in the USA since 2011.The impact of CMA results on clinical practice in China is no
Inhibitory GABAergic intemeurons are fundamental elements of cortical circuits and play critical roles in shaping network activity.Dysfunction of interneurons can lead to various brain disorders,including epilepsy,schizophrenia,and anxiety.Based on the el
The default mode network (DMN) is associated with the occurrence of mind-wandering or task-unrelated thought.In contrast,the frontal-parietal network (FPN) and visual network (VS) are involved in tasks with external stimuli.However,it is not clear how the
Autophagy is an evolutionarily-conserved self-degradative process that maintains cellular homeostasis by eliminating protein aggregates and damaged organelles.Recently,vesicle-associated membrane protein-associated protein B (VAPB),which is associated wit
Increasing evidence suggests that low to moderate ethanol ingestion protects against the deleterious effects of subsequent ischemia/reperfusion;however,the underlying mechanism has not been elucidated.In the present study,we showed that expression of the
Cognition and pain share common neural substrates and interact reciprocally:chronic pain compromises cognitive performance,whereas cognitive processes modulate pain perception.In the present study,we established a non-drug-dependent rat model of context-b
The ventral pallidum (VP) is a crucial component of the limbic loop of the basal ganglia and participates in the regulation of reward,motivation,and emotion.Although the VP receives afferent inputs from the central histaminergic system,little is known abo