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目的了解吸毒人群中HAV、HEV重叠感染状况及其影响因素。方法现况研究,整群抽样法抽取某女性戒毒所和某男性戒毒所中吸毒人员596名,收集有关资料并采集血清标本。用酶联免疫吸附试验(ELISA)检测血清中抗-HAVIgG及抗-HEVIgG,采用Chi-square检验和Logistic回归分析对数据进行统计学处理。结果抗-HAVIgG及抗-HEVIgG均为阳性者22例,重叠感染率3.69%(22/596)。经χ2检验,不同年龄(χ2=2.605,P=0.272)、不同文化程度(χ2=1.974,P=0.160)、是否饮用生水(χ2=0.460,P=0.497)、家庭成员有无肝炎病史(χ2=2.008,P=0.156)的HAV、HEV重叠感染率差异无显著性。经Logistic回归分析,年龄(OR=1.72)、文化程度(OR=2.29)、家庭成员肝炎病史(OR=2.08)与吸毒者HAV、HEV重叠感染相关。结论吸毒人群是HAV、HEV重叠感染的高危人群,年龄增大、文化程度低、家庭成员肝炎病史可能是吸毒人群中HAV、HEV重叠感染的危险因素。
Objective To understand the status of overlap infection of HAV and HEV in drug users and its influencing factors. Methodological study, cluster sampling method to extract a female drug addicts and a male drug addicts in drug addicts 596, collect the relevant information and collect serum samples. Serum anti-HAV IgG and anti-HEVIgG were detected by enzyme-linked immunosorbent assay (ELISA), and the data were statistically analyzed by Chi-square test and Logistic regression analysis. Results 22 cases were positive for anti-HAVIgG and anti-HEVIgG, and the overlap infection rate was 3.69% (22/596). (Χ2 = 2.605, P = 0.272), different education level (χ2 = 1.974, P = 0.160), raw water consumption (χ2 = 0.460, P = 0.497), family members with or without hepatitis history (χ2 = χ2 = 2.008, P = 0.156) HAV, HEV overlap infection rate difference was not significant. Logistic regression analysis showed that age (OR = 1.72), education level (OR = 2.29), history of hepatitis in family members (OR = 2.08) were associated with overlap of HAV and HEV among drug users. Conclusions The drug addicts are HAV and HEV patients with high risk of overlapping infection. Their age and education level are low. The history of hepatitis in family members may be the risk factors of HAV and HEV overlap infection in drug addicts.