论文部分内容阅读
蒽环类是一类广谱抗肿瘤药,其作用机制为直接嵌入细胞核碱基对之间,干扰转录过程,抑制DNA和RNA聚合酶,阻止细胞核酸的合成,是一细胞周期非特异性药物。由于其抗肿瘤活性强,在肿瘤联合用药及综合治疗中占有很重要的地位,临床上主要用于急、慢性白血病、恶性淋巴瘤、乳腺癌、骨肉瘤、肺癌及多种其它实体瘤。但其毒性也较大,除胃肠道反应、脱发、局部刺激、肝功能损害等不良反应外,还
Anthracyclines are a class of broad-spectrum anti-tumor drugs whose mechanism of action is that they directly intercalate between nucleobase pairs, interfere with the transcription process, inhibit DNA and RNA polymerase, and prevent the synthesis of cellular nucleic acids. It is a cell cycle nonspecific drug. Due to its strong antitumor activity, it plays a very important role in the combination therapy of tumors and in the treatment of acute and chronic leukemia, malignant lymphoma, breast cancer, osteosarcoma, lung cancer and many other solid tumors. But its toxicity is also greater, in addition to gastrointestinal reactions, hair loss, local irritation, liver damage and other adverse reactions