论文部分内容阅读
目的 探讨18F -脱氧葡萄糖 (FDG)正电子发射型体层摄影术 (PET)全身显像在原发灶不明转移癌中的作用。方法 对 2 9例原发灶不明转移癌患者行FDGPET全身显像 ,并与临床随诊、组织活检和手术病理结果对照。结果 2 9例原发灶不明转移癌患者 ,FDGPET发现可疑原发灶 15例 ,其中 13例为病理结果所证实 ,2例病理结果为阴性 ,FDGPET对原发灶的检出率为 44 .8% (13/2 9)。FDGPET全身显像另外检出淋巴结转移和远地转移灶 2 6个 ,CT和 (或 )MRI只检出 13个。 14例FDGPET未确定原发灶者 ,经随访 3～ 13个月 ,死亡率为 42 .9% (6 / 14)。 13例FDGPET确定原发灶者 ,经过有针对性的治疗 ,经随访 2～ 13个月 ,死亡率为 15 .4% (2 / 13)。结论 FDGPET全身显像对原发灶不明转移癌原发灶的确定、临床分期、治疗方案的制定以及预后的改善均有一定的价值。
Objective To investigate the role of 18F-FDG positron emission tomography (PET) in the diagnosis of primary carcinoma with unknown metastasis. Methods Twenty-nine patients with primary malignant tumor of unknown metastases underwent FDG PETET and compared with clinical follow-up, biopsy and surgical pathology. Results Twenty-nine cases of primary carcinoma with unknown metastatic disease were found. FDGPET found 15 cases of suspected primary tumor, of which 13 cases were confirmed by pathological results, 2 cases were negative and FDG PETET 44.8 % (13/2 9). In addition, 26 cases of lymph node metastasis and distant metastasis were detected by FDG PET and 13 cases were detected by CT and / or MRI. Fourteen patients with undetermined primary FDG PET were followed up for 3 to 13 months with a mortality rate of 42.9% (6/14). Thirteen patients with primary focal lesion confirmed by FDG PET were treated with targeted therapy. The mortality rate was 15.4% (2/13) after 2 to 13 months of follow-up. Conclusion The FDG PETET system has certain value in the determination of the primary tumor, the clinical stage, the treatment plan and the prognosis of the primary tumor with unknown metastasis.