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目的:探讨原发性肝细胞性肝癌超声造影表现与其生物学特性的关系。方法:原发性肝细胞性肝癌患者89例113个病灶,选择动脉相灌注特征、超声造影增强后肿瘤大小变化等生物学参数进行观察。全部病例经病理证实并与分级对照,部分病例检测微血管密度。结果:依超声造影改变将原发性肝细胞性肝癌灌注显像分为4型:树枝型、混合型、环绕型、网络型。综合超声造影灌注特征、病理、微血管密度、预后等多个参数,树枝型为浸润性生长,环绕型为膨胀性生长,其余2型介于二者之间为过渡型。结论:超声造影动脉期灌注显像特征及强化后肿瘤大小及轮廓的变化,反映了原发性肝细胞性肝癌生长方式及微血管密度与部位,可作为评估原发性肝细胞性肝癌生物学行为方法。
Objective: To investigate the relationship between CEA and its biological characteristics in primary hepatocellular carcinoma. Methods: A total of 113 lesions of 89 patients with primary hepatocellular carcinoma (HCC) were enrolled in this study. Biological characteristics such as arterial phase perfusion characteristics and tumor size after contrast enhanced ultrasound were observed. All cases were confirmed by pathology and grading control, in some cases the detection of microvessel density. Results: According to the changes of contrast-enhanced ultrasound, perfusion imaging of primary hepatocellular carcinoma was divided into 4 types: twig type, mixed type, surrounding type and network type. According to the characteristics of angiography perfusion, pathology, microvessel density, prognosis and other parameters, the twig type is infiltrative growth type, the surrounding type is expansive type growth, and the other two types are transitional type. CONCLUSIONS: The characteristics of arterial phase perfusion imaging and changes of tumor size and contour after ultrasound contrast, reflecting the growth pattern of primary hepatocellular carcinoma and the density and location of microvessel, can be used as a measure to evaluate the biological behavior of primary hepatocellular carcinoma method.