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目的了解发热伴血小板减少综合征布尼亚病毒(SFTSV)感染病例的临床及流行病学特征。方法收集2013年5月在宁波市传染病医院救治的1例重症发热伴血小板减少综合征(SFTS)患者资料,采集患者血标本、蜱进行实时荧光RT-PCR检测。结果 SFTS患者临床表现为持续高热、肌肉酸痛、双侧腹股沟淋巴结肿大和牙龈持续出血,急性期WBC、PLT呈进行性下降,转氨酶、心肌酶谱异常升高,患者血标本经检测SFTSV核酸阳性,并分离到新型布尼亚病毒,4只蜱经检测均为阴性。患者发病前无外出史和类似病例接触史,也无明确的蜱叮咬史。结论 SFTS病情重,常伴多脏器功能损害;本土疫源性可能大,除了蜱叮咬和接触传播途径之外,SFTSV还应存在其他传播途径。
Objective To investigate the clinical and epidemiological characteristics of feverish with thrombocytopenic syndrome (IBD) infection of Bunyavirus (SFTSV). Methods One patient with severe fever and thrombocytopenia (SFTS) who were treated in Ningbo Infectious Disease Hospital in May 2013 was collected. Blood samples were collected from patients and ticks were detected by real-time fluorescent RT-PCR. Results The clinical manifestations of SFTS were persistent fever, muscle soreness, bilateral inguinal lymph node enlargement and continuous gum bleeding. The WBC and PLT were decreased in the acute stage and the abnormal aminotransferase and myocardial enzymes were elevated. The SFTSV nucleic acid was detected in the blood samples, The new Bunyavirus was isolated and 4 ticks were tested negative. No history of outpatients before onset and similar cases of contact history, there is no clear history of tick bites. Conclusion SFTS is a serious disease with multiple organ dysfunction. The foci of the SFTSV may be large. Besides the tick bites and the route of contact transmission, SFTSV should have other routes of transmission.