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研究背景］通过对２４例侵蚀性葡萄胎的化学疗法，进一步探讨化学疗法在治疗中的作用．［病例报告］侵蚀性葡萄胎２４例，以年龄在４０岁以上、无生育要求、化学疗法中子宫明显增大、大出血等为指征，９例进行了子宫切除术、剖宫清宫术，为术后化学疗法创造条件．化学疗法以５氟尿嘧啶为主，附以５氟尿嘧啶加更生霉素或氨甲蝶呤联合化学疗法．Ⅰ期患者１３例平均行化学疗法３２个疗程，治愈率达１００％，Ⅱ期患者６例平均行化学疗法１７个疗程，３例治愈，Ⅲ期患者５例平均行化学疗法２８个疗程，２例治愈．［病例讨论］化学疗法结束２周后，进行血绒毛膜促性腺激素、Ｂ型超声波、Ｘ线胸片等检查，以观察疗效．Ⅱ，Ⅲ期中分别有３例放弃治疗．坚持随访治愈的１８例，至今未复发．［结论］５氟尿嘧啶、５氟尿嘧啶加更生霉素联合化学疗法疗效肯定，是治疗侵蚀性葡萄胎的首选疗法
Background] Through the chemotherapy of 24 cases of invasive hydatidiform mole, further explore the role of chemotherapy in the treatment. [Case Report] Twenty-four cases of invasive hydatidiform mole, with age over 40 years of age, no fertility requirements, significantly increased in the chemotherapy of the uterus, hemorrhage and other indications, 9 cases of hysterectomy, cesarean section, Postoperative chemotherapy to create conditions. Chemotherapy with 5-fluorouracil-based, attached to 5-fluorouracil plus dactinomycin or methotrexate combined with chemotherapy. In 13 cases of stage Ⅰ, the average chemotherapy was 32 courses, the cure rate was 100%. In stage Ⅱ, 6 cases were treated with 17 courses of chemotherapy on average, 3 cases were cured, and 5 cases of stage Ⅲ were treated with chemotherapy 2 8 courses, 2 cases of cure. [Case discussion] 2 weeks after the end of chemotherapy, blood chorionic gonadotropin, B ultrasound, chest X-ray and other tests to observe the effect. Three patients in stage Ⅱ and Ⅲ gave up treatment respectively. Adhere to follow-up cured 18 cases, has not relapsed. [Conclusion] 5-Fluorouracil, 5-Fluorouracil and Dactinomycin combined with chemotherapy have a positive curative effect, which is the first choice for the treatment of invasive hydatidiform mole