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目的评价早期帕金森病(PD)患者和原发性震颤(ET)患者的自主神经功能。方法选择89例PD患者和53例ET患者,PD患者行统一帕金森病评定量表运动部分(UPDRS-Ⅲ)评分及HoehnandYahr分期评定,ET患者行震颤量表(TRS)评分。两组患者均完成PD自主神经功能调查问卷(SCOPA-AUT)。结果 PD患者的SCO-PA-AUT总分、胃肠道症状、泌尿系统症状、心血管系统症状、体温调节功能、瞳孔调节功能的评分均高于ET患者和对照组(P<0.05或P<0.01),ET患者的SCOPA-AUT总分、泌尿系统症状、体温调节功能的评分高于正常对照组(P<0.05)。胃肠道和泌尿系统功能障碍在多巴胺能药物治疗的PD患者更常见。结论早期PD患者的自主神经功能障碍较ET患者和正常对照组更常见,PD患者的胃肠道和泌尿系统功能障碍可能与多巴胺能药物治疗有关。
Objective To evaluate the autonomic nervous system function in patients with early Parkinson’s disease (PD) and patients with essential tremor (ET). Methods Eighty-nine patients with PD and 53 patients with ET were enrolled in this study. Patients with PD were evaluated by UPDRS-III and Hoehnand Yahr staging, and tretinous rating scale (TRS) was used in patients with PD. Two groups of patients completed PD autonomic nervous system function questionnaire (SCOPA-AUT). Results The scores of SCO-PA-AUT, gastrointestinal symptoms, urinary symptoms, cardiovascular system symptoms, body temperature regulation and pupil adjustment in PD patients were significantly higher than those in ET patients and controls (P <0.05 or P < 0.01). The score of SCOPA-AUT score, urological symptom and body temperature regulating function in ET patients were higher than those in normal control group (P <0.05). Gastrointestinal and urinary dysfunction are more common in dopaminergic PD patients. Conclusion Early autonomic dysfunction in PD patients is more common than ET patients and normal controls. The gastrointestinal and urinary system dysfunction in patients with PD may be related to dopaminergic drug treatment.