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阻塞性睡眠呼吸暂停(OSA)可由上呼吸道解剖学异常引起,睡眠时肌纤维异常亦为一重要致病因素.早期 OSA 的表现为习惯性打鼾.研究13例需行喉切除术的男性喉癌患者均无上呼吸道阻塞及其他疾病,无放疗、化疗史.其中9例为不打鼾患者,年龄36～61岁,体重指数(BMI)平均26.4;4例为习惯性打鼾患者,年龄58～68岁,BMI 平均26.7.所有的肌肉标本均取自喉切除术患者的舌骨突部1cm 处的中咽缩肌(MPCM),经组织学和组织化学处理后,分析肌纤维中Ⅰ、Ⅱa、Ⅱb 型纤维的含量及大小。结果患者的 MPCM 纤维的组织学特征与正常
Obstructive sleep apnea (OSA) can be caused by anatomical abnormalities of the upper respiratory tract, and abnormality of the muscle fiber during sleep is also an important causative factor. Early OSA manifests as habitual snoring. Study of 13 male laryngeal cancer patients undergoing laryngectomy None of the patients had upper respiratory blockage or other diseases, no history of radiotherapy or chemotherapy, and 9 of them were non-snoring patients, ranging in age from 36 to 61 years with an average body mass index (BMI) of 26.4. Four patients were habitual snorers, ranging in age from 58 to 68 years , And the average BMI was 26.7. All muscular specimens were collected from the pharyngeal constrictor (MPCM) at 1 cm of the hyoid bone in patients undergoing laryngectomy. After histological and histochemical treatment, the muscle fibers of type Ⅰ, Ⅱa and Ⅱb Fiber content and size. Results The patient’s histological features of MPCM fibers were normal