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已知组胺和5-羟色胺(5-HT)可能与丛集性头痛(CH)的发病机理有关。本文调查了在CH 发作期间,颞浅动脉(STA)附近是否有5-HT和组胺释放。方法共11例(26～57岁)男性病人符合国际头痛学会有关 CH 的诊断标准,1例为慢性,10例为发作性 CH。研究前3天均未接受预防性治疗。将微探子置于痛侧 STA 附近,并沿 STA走行植入导管,该导管距动脉2～3cm。然后分别采集全部病例非发作期的样本,4例还每3小时一次,采集发作期的标本。结果全部病人的发作期或发作间期的标本均未测到组胺。无发作的7例病人样本中,5-HT 仅含微量或不可能测到。发作前标本的5-HT 平均浓度为41±10mol/20μl(30～65,n=47),发作后3分钟升至51±11foml/20μl(43～66,n=4),而在 CH 发作期间5-HT 浓度骤升至143±30fmol/20μl(90～250,n=4)。经统计学处理,发作期间与发作前或发作后3分钟的5-HT浓度存有显著差异(P<0.05)。发作期间 5-HT
Histamine and serotonin (5-HT) are known to be involved in the pathogenesis of cluster headache (CH). This article investigated whether there was 5-HT and histamine release near the superficial temporal artery (STA) during CH episodes. Methods A total of 11 male patients (26-57 years) who met the diagnostic criteria of International Headache Association for CH, one was chronic and the other 10 were episodes of CH. Neither did preventive treatment for the first 3 days of the study. The probe is positioned near the painful side of the STA and implanted along the STA with a catheter that is 2 to 3 cm from the artery. Then all the cases were collected non-episodes of the sample, 4 cases also once every 3 hours, the acquisition of specimens during the attack. Results No histamine was detected in all patients during the seizure or interictal period. Of the 7 patients without seizures, 5-HT contained only trace amounts or could not be measured. The average 5-HT concentration in pre-seizures was 41 ± 10 mol / 20 μl (30-65, n = 47) and increased to 51 ± 11 foml / 20 μl (43-66, n = 4) at 3 minutes after seizure. During the 5-HT concentration was increased to 143 ± 30fmol / 20μl (90 ~ 250, n = 4). Statistically, there was a significant difference (P <0.05) in the 5-HT concentrations between pre-seizure and post-seizure 3 minutes. Attack during 5-HT