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目的系统评价中国人ORMDL3基因rs72l6389多态性与哮喘易感性的相关性。方法计算机检索Pub Med、EMbase、The Cochrane Library(2014年第8期)、CBM、CNKI、VIP和Wan Fang Data,查找国内外关于ORMDL3基因rs72l6389多态性与中国人哮喘相关性的病例-对照研究,检索时限均为从建库至2014年8月。由2位研究者按纳入与排除标准独立筛选文献、提取资料并评价纳入研究的方法学质量后,采用Rev Man 5.2软件进行Meta分析,并采用Stata 11.0进行发表偏倚评估。结果共纳入7个病例-对照研究,合计1 711例哮喘患者和1 763例对照。Meta分析结果显示,ORMDL3基因rs72l6389多态性与中国人哮喘易感性具有相关性[OR=0.71,95%CI(0.62,0.81),P<0.000 01]。按年龄进行亚组分析结果提示,ORMDL3基因rs72l6389多态性与成人哮喘[OR=0.71,95%CI(0.61,0.83),P<0.000 1]和儿童哮喘[OR=0.69,95%CI(0.52,0.90),P=0.006]发病具有相关性。结论ORMDL3基因rs72l6389多态性是中国人成人和儿童哮喘发病的危险因素。
Objective To systematically evaluate the association between rs72l6389 polymorphism of Chinese ORMDL3 gene and susceptibility to asthma. Methods PubMed, EMbase, The Cochrane Library (No. 8, 2014), CBM, CNKI, VIP and Wan Fang Data were searched by computer to find the case-control study on the association between ORMDL3 rs72l6389 polymorphism and Chinese asthma , Search time are from the database to August 2014. Two researchers independently screened the literature for inclusion and exclusion criteria, extracted data, and assessed the methodological quality of the included studies. Meta-analysis was performed using Rev Man 5.2 software and published for publication bias using Stata 11.0. Results A total of 7 case-control studies were included, totaling 1 711 asthmatics and 1 763 controls. Meta-analysis showed that rs72l6389 polymorphism of ORMDL3 gene was associated with susceptibility to asthma in Chinese [OR = 0.71, 95% CI (0.62, 0.81), P <0.000 01]. A subgroup analysis by age suggested that rs72l6389 ORMDL3 polymorphism was associated with asthma in adults [OR = 0.71, 95% CI (0.61, 0.83), P <0.0001] and childhood asthma [OR = 0.69, 95% CI , 0.90), P = 0.006]. Conclusion The rs72l6389 polymorphism of ORMDL3 gene is a risk factor for asthma in Chinese adults and children.