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联合应用二种或二种以上的药物,常可增强疗效,减少不良反应.但联合不当则可产生不良后果。了解抗心律失常药之间及与其它药物的相互作用尤为重要。近年来不仅在临床上观察了药效学和药动学方面的相互作用,并运用分子生物学理论阐明了某些相互作用的基础。本文扼要介绍这方面的概况并讨论临床应用的有关问题。一、慢心律(一)、具有协同作用的药物1.β-受体阻滞剂低于有效剂量的慢心律加用心得安(240mg/天)在控制室性早搏(室
Combined use of two or more drugs, often can enhance the efficacy and reduce adverse reactions, but improper combination can have adverse consequences. It is particularly important to understand the interaction between antiarrhythmic drugs and other drugs. In recent years, not only the clinical observation of pharmacodynamics and pharmacokinetic interactions, and the use of molecular biology theory to clarify the basis for some of the interactions. This article gives an overview of this area and discusses the issues related to clinical use. First, the slow heart rhythm (a), synergistic drugs 1. β-blockers lower than the effective dose of slow heart rate plus propranolol (240mg / day) in the control of ventricular premature beats (room