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硫酸锌眼药水是一种具有收敛,防腐,用于治疗慢性结膜炎和沙眼的常用制剂,配制该制剂时常加入氯化苯甲烃铵0.01%(洁尔灭),硫柳汞或0.01%新洁尔灭作为抑菌剂,我院制剂室在配制该制剂时常采用后者,但我们在对该制剂测定含量时发现,新洁尔灭对滴定有干扰,终点不明显(无酒红到纯兰的突变)。我们分析可能是新洁尔灭季铵阳离子的干扰,根据阳离子表面活性剂的作用可以被阳离子表面活性剂对抗的理化,我们设想
Zinc sulfate eye drops is a convergence, antisepsis, used for the treatment of chronic conjunctivitis and trachoma commonly used formulations, preparation of the formulation often added benzalkonium chloride 0.01% (benzalkonium bromide), thimerosal or 0.01% benzalkonium bromide as a Mycotoxin, our hospital preparation room in the preparation of the preparation often use the latter, but we measured the content of the preparation and found that benzalkonium bromide on the titration interference, the end point is not obvious (no wine red to pure blue mutation). Our analysis may be the interference of the Brjam quaternary ammonium cation, which can be antagonized by the cationic surfactant according to the action of the cationic surfactant