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本文旨在探讨不同剂量的汉防己甲素或梯络龙分别与克矽平联合用药治疗实验性矽肺,并与单一用药组进行疗效比较。实验共分为11组,各组疗程均为三个月。实验结果表明:以汉防己甲素(简称汉甲)半有效剂量(10mg/kg)或梯络龙半有效剂量(10mg/kg)分别与克矽平联合用药,其疗效与单一用药的全剂量组(20mg/kg)的疗效基本相同,而各药物在肝脏内的蓄积量均比单独用药的全剂量组明显减少。因此采用联合用药,可提高疗效及减低药物的毒副作用,是一种较好的用药方案。
The purpose of this study was to investigate the effects of different doses of tetrandrine or fluolone on the treatment of experimental silicosis in combination with KeziPing, and to compare the efficacy with that of the single drug group. The experiment was divided into 11 groups, and each group was treated for three months. The experimental results show that: a semi-effective dose of tetrandrine (abbreviated to Han) is given as a combined dose of 10 mg/kg or 10 mg/kg of diterpenoids in combination with Kefuping. The efficacy of the group (20 mg/kg) was basically the same, and the accumulation of each drug in the liver was significantly lower than that of the single dose group. Therefore, the combination of drugs can improve the efficacy and reduce the toxic side effects of drugs, is a better medication program.