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目的:评价以牛骨作为义眼座在兔眼眶内植入的生物相容性。方法:在兔眼中用牛骨作为植入物,观察其生物相容性及其能否取代昂贵的人造植入物。把12只眼球内容摘除术后的新西兰白兔按眶内有没有植入牛骨分为两组:Y组(6只)为眼球摘除术后眶内没有植入牛骨,X组(6只)为眼球摘除术后植入牛骨。对12只新西兰白兔右眼行眼球内容物摘除,其中6例作为实验组行牛骨植入,6例作为对照组不植入。术后1,7,14,28,42d连续观察术眼的感染情况,植入物的移位情况,伤口愈合情况,眼球运动是否受限。术后42d,摘除实验组眼球,行组织病理检查,检测其炎性反应类型以及纤维血管增生情况。结果:连续临床观察显示:试验组和对照组在术后1d都有轻微的炎症反应,抗生素控制有效。试验组有1例在术后1d发生感染。但没有植入物的移位和脱出,没有伤口的裂开和眼球运动受限,也没有严重的感染和畸形出现。组织病理检查显示牛骨纤维生长良好,有轻微的排斥反应。结论:实验表明在兔眼中,牛骨作为义眼座植入有良好的生物相容性,而且其成本较低,易被接受。
OBJECTIVE: To evaluate the biocompatibility of bovine bones as orbital implant in rabbits. METHODS: Bovine bones were used as implants in rabbits to observe their biocompatibility and whether they could replace expensive artificial implants. Twelve eyes of New Zealand white rabbits were divided into two groups according to whether or not bovine bone was implanted in the orbital tissue. Group Y (n = 6) received no orbital implantation of bovine bone after enucleation. Group X (n = 6 ) For the implantation of bovine after enucleation. Right eyes of 12 New Zealand white rabbits underwent ocular excision. Six of them were implanted as bovine bone in the experimental group and six as a control group. The postoperative 7th, 7th, 14th, 28th and 42th days of continuous observation of eye infection, displacement of implants, wound healing and eye movement were limited. At 42 days after operation, the eyeballs of experimental group were removed, histopathological examination was performed, and the type of inflammatory reaction and fibrovascular hyperplasia were detected. Results: The continuous clinical observation showed that the experimental group and the control group had slight inflammatory reaction on the 1st day after operation, and the antibiotic control was effective. One patient in the test group had an infection at 1 day after operation. However, there was no displacement or prolapse of the implants, no splitting of the wounds and restricted eye movement, and no serious infections and deformities. Histopathological examination showed that the bovine bone fiber grew well with a slight rejection. CONCLUSIONS: Experiments have shown that bovine bones are good biocompatible implants in the eye of rabbits and are less costly and easily accepted.