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目的选择乙型肝炎病毒(HBV)经手术感染外科医生的防护方法。方法在比较东、西方国家现有HBV经手术传播防护方法的基础上,阐述以乙型肝炎e抗原(HBeAg)作为手术期间HBV传染源监控指标的特点。结果乙型肝炎表面抗原(HBsAg)、HBeAg阴性者和HBeAg阳性者的HBV浓度分别为(100~104)、(100~106)(、102~109)ID/ml;HBV经单层手套传播的感染阈值为105ID/ml,经双层手套传播的感染阈值为106ID/ml;HBsAg阴性者的病毒浓度均达不到手术感染阈值,83.88%HBeAg阳性者的病毒浓度达到手术感染阈值,有80.65%在乙型肝炎疫苗低度反应者的防护范围之内,其余3.23%超过了这种防护能力。结论以HBeAg作为手术期间HBV传染源监控指标的方法属零危险性防护标准,更适合我国现在的国情。
Objective To select surgical methods for the protection of hepatitis B virus (HBV) in surgeons. Methods Based on the comparison of existing HBV transmission prevention methods in East and West countries, the etiological factor of hepatitis B e antigen (HBeAg) was defined as the indicator of HBV infection during operation. Results The HBV levels of HBsAg, HBeAg-negative and HBeAg-positive were (100-104), (100-106) (, 102-109) ID / ml, respectively. The threshold of infection was 105ID / ml. The infection threshold transmitted by double gloves was 106ID / ml. The virus concentration of HBsAg negative patients did not reach the threshold of surgical infection. The virus concentration of 83.88% HBeAg positive patients reached the threshold of surgical infection, with 80.65% The remaining 3.23% exceeded this protective ability within the protection of hepatitis B vaccine responders. Conclusion HBeAg as the indicator of HBV infection source during operation is a zero-risk protection standard, which is more suitable for our country’s current national conditions.