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作者等报导,唇形科山香属植物Hyptis emoryi Torr.的地上部分(茎、叶和花)的氯仿提取物对大鼠瓦克氏癌-256(肌肉注射)有一定疗效,在600毫克/公斤和400毫克/公斤剂量时对Sprague大鼠的抑瘤率分别为64%和53%。化学预试提示,有效物质为萜类化合物。经丙酮和石油醚分离得有效部位含两种萜类化合物(A和B),硅胶-G薄层层析,氯仿-丙酮(9∶1)展开。再经硅胶G干柱层析法层析,用氯仿-二氧六环(9∶1)洗脱得化合物A。A在500毫克/公斤时抑瘤率为85%,300毫克/公斤为48%。该化合物用丙酮-四氢呋喃,甲醇重结晶得无色长针晶,熔点291～293℃,[α]_D+6.77(吡啶),四硝基甲
The authors reported that the chloroform extract of the aerial parts (stem, leaf and flower) of Hyptis emoryi Torr. Had a certain effect on rat Wacker’s’s Carcinoma-256 (intramuscular injection) at 600 mg / kg The inhibitory rates to Sprague rats at the dose of 400 mg / kg were 64% and 53%, respectively. Chemical pre-test tips, the effective substance is a terpenoid. After separation from acetone and petroleum ether, two terpenoids (A and B) were obtained. Silica gel-G thin-layer chromatography and chloroform-acetone (9: 1) were developed. Chromatography on silica gel G, eluting with chloroform-dioxane (9: 1) afforded Compound A. The inhibition rate of A was 85% at 500 mg / kg and 48% at 300 mg / kg. The compound was recrystallized from acetone-tetrahydrofuran and methanol to give colorless long needles, mp 291-293 ° C, [α] D + 6.77 (pyridine), tetranitro-methyl