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目的分析温州市超重肥胖少年儿童的临床特征。方法本研究为病例对照横断面研究。入组对象来源于2012年1月—2014年12月在温州医科大学附属第二医院暨育英儿童医院体检中心体检的6~16岁的中小学生,研究对象分为肥胖组、超重组、正常组,分别记录性别、年龄、身高、体重,计算BMI,并检测肝脏B超、空腹血糖、空腹胰岛素、肝功能、肾功能、血脂,计算HOMA-IR、HOMA-B。结果共有312例少年儿童纳入研究,其中肥胖组109例,超重组89例,正常组114例。超重及肥胖少儿的谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转肽酶(GGT)高于体重正常少儿(P<0.01及P<0.05);超重及肥胖少儿总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)均高于而高密度脂蛋白胆固醇(HDL-C)低于体重正常少儿(P均<0.05);肥胖少儿脂肪肝的患病状态高于超重和体重正常少儿(49%vs.0%,8%vs.0%,P均<0.01);超重及肥胖少儿的空腹胰岛素及胰岛素抵抗指数高于体重正常少儿(P均<0.01)。结论超重肥胖少年儿童已经表现出明显的胰岛素抵抗特征,如转氨酶的升高,血脂异常,脂肪肝患病率明显升高。
Objective To analyze the clinical features of overweight and obesity children in Wenzhou. Methods This study was a case-control cross-sectional study. Participants from January 2012 to December 2014 in the Second Affiliated Hospital of Wenzhou Medical University and Yuying Children’s Hospital physical examination of 6 to 16-year-old primary and secondary school students, the study was divided into obesity group, overweight group, normal group The BMI, BMI, fasting blood glucose, fasting insulin, liver function, renal function, blood lipids, HOMA-IR and HOMA-B were calculated respectively by gender, age, height and weight. Results A total of 312 children and adolescents were included in the study, of which 109 were obese, 89 were overweight, and 114 were normal. The levels of ALT, AST and GGT in overweight and obese children were significantly higher than those in normal weight children (P <0.01 and P <0.05). The levels of total cholesterol ), Triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) were higher than that of HDL-C in children with normal weight (P <0.05) (49% vs.0%, 8% vs.0%, P <0.01). The fasting insulin and insulin resistance index of overweight and obese children were higher than those of normal weight children (P < <0.01). Conclusion Overweight and obesity children have shown obvious insulin resistance characteristics, such as elevated aminotransferases, dyslipidemia, fatty liver was significantly higher prevalence.