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目的:联合检测外周血白介素-17(IL-17)及C-反应蛋白(CRP)在不同程度脓毒症患者中的表达。方法:收集2015年5月—2016年5月住院的52例脓毒症患者,并据感染程度分为脓毒症组(24例)、脓毒症休克组(28例)。患者入院24小时及治疗后3天分别应用ELISA检测外周血白介素-17及C-反应蛋白水平,采用SPSS17.0软件进行统计分析。结果:对照组、脓毒症组及脓毒症休克组外周血IL-17检测结果分别是:21.58±4.89,23.95±7.10,75.31±23.04,组间差异有显著性统计学意义(t=87.8687,p<0.05);结论:外周血IL-17及CRP均与脓毒症的严重程度呈正相关,外周血IL-17和CRP联合动态监测可作为脓毒症疗效判定的良好指标。
Objective: To detect the expression of interleukin-17 (IL-17) and C-reactive protein (CRP) in peripheral blood of patients with sepsis. Methods: Fifty-two patients with sepsis who were hospitalized from May 2015 to May 2016 were divided into sepsis group (24 cases) and septic shock group (28 cases) according to the degree of infection. Serum levels of IL-17 and C-reactive protein were measured by ELISA at 24 hours after admission and 3 days after treatment respectively. Statistical analysis was performed by SPSS17.0 software. Results: The levels of IL-17 in peripheral blood of the control group, sepsis group and septic shock group were 21.58 ± 4.89, 23.95 ± 7.10 and 75.31 ± 23.04, respectively, with significant difference between the two groups (t = 87.8687 , p <0.05). CONCLUSION: The levels of IL-17 and CRP in peripheral blood are positively correlated with the severity of sepsis. The combination of IL-17 and CRP in peripheral blood can be used as a good indicator of the efficacy of sepsis.