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目的探究脑梗死患者急性期以降纤酶治疗后凝血功能(APTT、PT)以及血液流变学变化情况。方法以2015年1月至2017年1月期间收治的96例脑梗死急性期者为研究对象,按随机排列法将患者分为两组,人数均为48例,其中对比组(维脑路通、右旋糖酐)、观察组(加用降纤酶),比较治疗前后患者凝血功能(APTT、PT)以及血液流变学指标(血浆黏度以及全血低切、全血高切黏度)改善情况。结果入院时凝血以及血液流变学指标组间比较差别无意义,P>0.05用药后使用降纤酶的观察组指标PT、APPTY以及血液流变学指标改善优于对比组,P<0.05。结论对急性期脑梗死患者治疗时使用降纤酶,能有效改善血液高凝状态,促进血液流变学指标恢复正常,对减轻脑损害有利。
Objective To investigate the changes of coagulation function (APTT, PT) and hemorheology in patients with acute cerebral infarction after defibrase treatment. Methods A total of 96 patients with acute cerebral infarction admitted from January 2015 to January 2017 were enrolled in this study. Patients were divided into two groups according to randomization method. The number of patients was 48, of which the control group , Dextran). The observation group (plus defibrase) was used to compare the changes of coagulation function (APTT, PT) and hemorheology indexes (plasma viscosity, whole blood low cut and whole blood high shear cut) before and after treatment. Results There were no significant differences between the groups in coagulation and hemorheology at admission. P> 0.05. The indexes of PT, APPTY and hemorheology in the observation group after defibrase were better than those in the control group (P <0.05). Conclusion The use of defibrase during the treatment of patients with acute cerebral infarction can effectively improve the blood hypercoagulability and promote the normalization of hemorheological parameters, which is beneficial to relieve brain damage.