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目的了解河南省妇产科术后感染切口病原菌的分布及耐药状况,为临床抗菌药物的合理使用提供指导。方法对2013年1月—2015年12月间妇产科术后感染菌株利用手工实验及珠海迪尔DL-96系统相结合的方法进行细菌鉴定和药敏实验。结果参照美国CLSI标准,转入WHONET软件进行分析。结果河南省妇幼保健院妇产科3年妇产科术后切口感染患者切口的脓液,共检出268株细菌。其中革兰阴性菌以大肠埃希菌为最多,94株;革兰阳性菌以粪肠球菌为最多,68株。药敏结果显示大肠埃希菌对氨苄西林、头孢曲松等耐药率较高,对碳青霉烯类耐药率较低。粪肠球菌对红霉素、四环素等耐药率较高,对万古霉素、利奈唑胺耐药率较低。结论妇产科术后感染切口病原菌分布较特殊,对各类抗菌药物耐药率不尽相同,应充分利用病原菌监测结果进行用药指导,以促进抗菌药物的合理使用。
Objective To understand the distribution and drug resistance of pathogenic bacteria in obstetrics and gynecology patients after incision in Henan province and provide guidance for the rational use of clinical antibacterials. Methods Bacterial identification and antimicrobial susceptibility tests were performed on the strains of post-gynecological infections infected by obstetrics and gynecology between January 2013 and December 2015 using a manual experiment and the Zhuhai Deir DL-96 system. Results with reference to the US CLSI standard, into WHONET software for analysis. Results Maternal and Child Health Hospital of Henan Province 3 years after obstetrics and gynecology incision infection in patients with pus, a total of 268 strains of bacteria were detected. Gram-negative bacteria which Escherichia coli is the most, 94 strains; Gram-positive bacteria to Enterococcus faecalis most, 68 strains. Drug susceptibility results showed that Escherichia coli had a higher resistance rate to ampicillin and ceftriaxone and a lower resistance rate to carbapenems. Enterococcus faecalis erythromycin, tetracycline and other higher rates of resistance to vancomycin, linezolid resistance was lower. Conclusion Obstetric and gynecological infection incision pathogen distribution is rather special, the rate of resistance to various antimicrobial drugs are not the same, should make full use of the results of pathogen monitoring drug guidance to promote the rational use of antimicrobial agents.