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目的：探讨产前综合性心理干预对围产期抑郁患者情绪及生活质量的影响。方法将497例围产期抑郁患者按产检号随机分为两组，研究组251例，对照组246例。两组均接受常规孕期保健宣教，研究组在此基础上联合综合性心理干预，于孕28周、36周及产后1个月采用焦虑自评量表、爱丁堡产后抑郁量表、生活质量量表进行测评分析。结果孕28周两组各量表评分比较差异无显著性（ P＞0．05）。孕36周及产后1个月两组焦虑自评量表、爱丁堡产后抑郁量表总分均较孕28周显著降低（ P＜0．05或0．01），研究组显著低于对照组（ P＜0．05或0．01）；研究组生活质量量表的精神成分及躯体成分维度分较孕28周显著升高（ P＜0．05或0．01），对照组仅躯体成分维度分较孕28周显著升高（ P＜0．01），研究组显著高于对照组（ P＜0．05或0．01）。结论综合性心理干预能显著改善围产期抑郁患者的焦虑抑郁情绪，提高患者的生活质量。“,”Objective To explore the effect of antenatal comprehensive psychological interventions on emo‐tions and quality of life of perinatal depression patients .Methods A total of 497 perinatal depression pa‐tients were assigned to research (n=251) and control group (n=246) according to obstetric examination number .Both groups received routine antenatal care education ,on this basis research group was plus com‐prehensive psychological interventions , and assessments conducted with the Self‐rating Anxiey Scale (SAS) ,Edinburgh Postnatal Depression Scale (EPDS) and MOS 12‐item Short Form Health Survey (SF‐12) within the week 28 and 36 of pregnancy as well as within 1 month after delivery .Results There were no significant group differences in all scales scores within Scores of EPDS and SAS significantly were sig‐nificantly lower in week 28 of pregnancy (P>0 .05) .The total scores of the SAS and EPDS of both groups within week 6 as well as within 1 month after delivery lowered more significantly compared with those within week 28 (P<0 .01) ,those were significantly lower in research than in control group (P<0 .05 or 0 .01);mental and physical dimension score of the SF‐12 heightened more significantly in research group (P< 0 .01) ,so did physical dimension score in control group (P< 0 .01) ,and those were significantly higher in research than in control group (P<0 .05 or 0 .01) .Conclusion Comprehensive psychological in‐tervention could notably improve anxious‐depressive emotions of perinatal depression patients and boost patients’ quality of life .