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目的研究用免疫组化方法检测胃癌淋巴结中微转移的临床病理意义.方法作者共检测了42例胃癌的1251只淋巴结,所有的肿瘤组织和淋巴结均分别用 HE 染色和抗角蛋白19抗体及抗 CEA抗体的免疫组化染色.结果用 HE 染色发现有377只(30.1%)淋巴结转移阳性,免疫组化染色发现共有463只(37.0%)淋巴结转移阳性,其中86只淋巴结只有微转移.42例胃癌中有19例患者的淋巴结中发现微转移,其中3例仅有微转移,占常规病理检查淋巴结转移阴性患者的27.3%(3/11).在弥漫型胃癌以及侵及浆膜的胃癌中,微转移阳性率显著高于其他肿瘤.结论免疫组化染色是检测胃癌淋巴结微转移的敏感方法,检测胃癌微转移有助于判断肿瘤进展程度.
Objective To study the clinicopathological significance of detecting micrometastasis in gastric lymph nodes by immunohistochemical method. METHODS: A total of 1251 lymph nodes were detected in 42 cases of gastric cancer. All tumor tissues and lymph nodes were stained with HE and anti-keratin 19 antibodies and antibodies respectively. Immunohistochemical staining of CEA antibody. Results 377 (30.1%) lymph node metastases were positive with HE staining. Immunohistochemical staining revealed a total of 463 (37.0%) lymph node metastases positive, of which 86 lymph nodes had only micrometastasis. 42 cases. In gastric cancer, micrometastasis was found in the lymph nodes of 19 patients, of which only 3 had micrometastasis, which accounted for 27.3% (3/11) of patients with negative lymph node metastases in routine pathological examinations. In diffuse gastric cancer and gastric cancer invaded by serosa The positive rate of micrometastasis was significantly higher than other tumors. Conclusion Immunohistochemical staining is a sensitive method to detect lymph node micrometastasis in gastric cancer. Detection of micrometastasis in gastric cancer is helpful to judge the degree of tumor progression.