论文部分内容阅读
现在普遍认为动脉粥样硬化(atherosclerosis,AS)是一种炎症,而单核/巨噬细胞的异常活动是引发这种炎症的关键因素,单核/巨噬细胞与AS发生和发展的各个阶段紧密相关。单核/巨噬细胞自身活动的相关领域以及它们在斑块部位与其他细胞的相互作用成为动脉粥样硬化新兴的治疗靶点。本文综述了从减少单核/巨噬细胞聚集、抑制氧化应激、调节巨噬细胞中的胆固醇代谢、减少巨噬细胞源性炎症反应、增加AS斑块稳定性等方面治疗AS的研究进展,旨在为抗动脉粥样硬化药物的临床使用和研究开发提供参考。
It is now generally accepted that atherosclerosis (AS) is an inflammation, and abnormal activity of monocytes / macrophages is a key factor triggering this inflammation, mononuclear / macrophage and AS stages of development and progression Closely related. Relevant fields of monocyte / macrophage self-activity and their interaction with other cells at the plaque site are emerging emerging therapeutic targets for atherosclerosis. This review summarizes the progress in the treatment of AS from reducing monocyte / macrophage aggregation, inhibiting oxidative stress, regulating cholesterol metabolism in macrophages, reducing macrophage-derived inflammatory responses and increasing plaque stability. Designed for anti-atherosclerotic drug clinical use and research and development provide a reference.