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目的 本文报道宫内血管内输血后,胎儿循环血中胎儿和供者红细胞数每日下降的比例。计划 回顾性分析101例胎儿的302次输血。背景 荷兰Leiden大学医学中心妇产科。方法 检测同种免疫病的胎儿反复宫内血管内输血前后胎儿血样的血细胞比容。胎儿红细胞百分率用Kleihauer-Betke染色涂片判定。胎儿、供者和混合红细胞数的下降由划分两次输血间每日的比容下降比例以及校正胎儿胎盘体积变化来计算。结果[给出均数(SD)]得自每天比容变化比例。结果 第一次与第二次输血时间间隔[15.5天(SD 5.2)],短于其后的输血时间间隔(平均在21.4～21.9天,P≤0.0001)。由于输血及胎儿的生长,子宫体积发生变化,但
Objective This article reports intrauterine vascular transfusions, fetal blood and fetal red blood cells in the number of daily decline in the ratio. We plan to retrospectively analyze 302 transfusions of 101 fetuses. Background The Department of Obstetrics and Gynecology, Leiden University Medical Center, The Netherlands. Methods The hematocrit of fetus blood samples before and after intrauterine blood transfusion in fetuses with alloimmune diseases were detected. Fetal red blood cell percentage using Kleihauer-Betke stained smears. The decrease in fetal, donor, and mixed red blood cell count was calculated by dividing the daily volume reduction between transfusions and correcting for fetal placental volume changes. The result [mean (SD) given] is derived from the daily specific volume change ratio. Results The first and second transfusion intervals [15.5 days (SD 5.2)] were shorter than the subsequent transfusion intervals (mean, 21.4-21.9 days, P ≤ 0.0001). Uterine volume changes due to blood transfusions and fetal growth