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该文系统地研究了羊源II型胶原蛋白(Type II collagen,CII)对小鼠佐剂性关节炎(Adjuvant arthritis,AA)的抑制作用,在致炎前14 d(预防组)、致炎同时(治疗组)经口插管灌胃法给予小鼠3 mg/(kg.d)CII灌胃,并于致炎后6、12、18和24 d时分批断颈处死小鼠,对小鼠血清中一氧化氮(Nitric Oxide,NO)、白细胞介素-1β(Inter-leukin-1,IL-1)、超氧化物岐化酶(Super oxide dismutase,SOD)和丙二醛(Malonyl dialdehyde,MDA)的含量变化进行研究。结果发现,口服CII可降低小鼠血清中NO、IL-1和MDA含量,同时使小鼠血清中SOD活性增强,抑制AA的发病,降低发病率,明显减轻病变关节的炎症反应并使病程缩短,预防组显著优于治疗组。
This article systematically studied the inhibitory effect of Type II collagen (CII) on adjuvant arthritis (AA) in mice, At the same time (treatment group), intragastric administration of 3 mg / (kg.d) CII was intragastrically administered to mice and the mice were sacrificed at 6, 12, 18 and 24 d after the inflammation, Serum levels of nitric oxide (NO), interleukin-1β (IL-1), superoxide dismutase (SOD) and malonyl dialdehyde, MDA) content changes were studied. The results showed that oral administration of CII can reduce the content of NO, IL-1 and MDA in the serum of mice, and increase the activity of SOD in the serum of mice at the same time, inhibit the incidence of AA, reduce the incidence, significantly reduce the inflammatory reaction and shorten the course of disease , Prevention group was significantly better than the treatment group.