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目的:采用Meta分析的方法对FCGR2A基因rs1801274位点多态性与川崎病相关性研究进行分析。方法:截至2016年8月,计算机检索英文数据库(PubMed、EMbase)及中文数据库[中国知网(CNKI)、维普期刊资源整合服务平台(VIP)和万方数据知识服务平台(Wanfang)、中国生物医学文献服务系统(Sino Med)]中rs1801274位点基因多态性与川崎病相关性研究。采用Stata 12.0软件进行Meta分析。结果:共纳入8篇文献,包括3 724例患儿(川崎病组)和14 278例对照(对照组)。rs1801274位点基因多态性在等位基因模型(A vs G)、共显性模型(AG vs GG、AA vs GG)、显性模型(AG+AA vs GG)和隐性模型(AA vs AG+GG)比较模型下均与川崎病患病风险增加相关,合并OR值及其95%CI分别为1.387(1.299~1.480)、1.501(1.072~2.102)、1.959(1.403~2.735)、1.736(1.258~2.396)、1.397(1.174~1.661)。各研究异质性检验、Begg’s检验和Egger’s检验均P>0.1。结论:rs1801274位点基因多态性与川崎病相关,A等位基因是发生川崎病的危险基因。
OBJECTIVE: To analyze the association between the rs1801274 polymorphism of FCGR2A gene and Kawasaki disease using Meta-analysis. METHODS: By August 2016, PubMed (EMbase) and Chinese databases (CNKI, VIP, and Wanfang), Chinese creatures Study on the Association of rs1801274 Gene Polymorphism with Kawasaki Disease in SinoMed. Meta-analysis was performed using Stata 12.0 software. RESULTS: Eight articles were included, including 3 724 children (Kawasaki disease group) and 14 278 controls (control group). The rs1801274 gene polymorphism was significantly higher in alleles (A vs G), co-dominant (AG vs GG, AA vs GG), dominant (AG + AA vs. GG) and recessive + GG) were all associated with the increased risk of Kawasaki disease.The combined OR and 95% CI were 1.387 (1.299-1.480), 1.501 (1.072-2.102), 1.959 (1.403-2.735), 1.736 (1.258 ~ 2.396), 1.397 (1.174 ~ 1.661). Each research heterogeneity test, Begg’s test and Egger’s test all P> 0.1. Conclusion: Polymorphism of rs1801274 is associated with Kawasaki disease, and A allele is a risk gene for Kawasaki disease.