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二叔丁基对甲酚(2,6-二叔丁基-4-甲基酚、BHT)是一种有效的抗氧剂,它具有广谱的药理活性。目前只有工业上生产的10％二叔丁基对甲酚灭菌搽剂,供膀胱癌和膀胱炎患者注入膀胱用。对口服剂型进行了研究,结果含0.3克的二叔丁基对甲酚片剂和锭剂的肠胃道吸收都很差,油溶液比片剂吸收好,但油溶液有苦味,并会引起噁心、呕吐和腹泻,故作者采用单凝聚法制成微囊剂型,其工艺过程如下: 将二叔丁基对甲酚在20℃于搅拌下溶于向日葵油制成20％的油溶液;另外分别制备10％明胶水溶液和20％硫酸钠溶液。先
Di-tert-butyl-p-cresol (2,6-di-tert-butyl-4-methylphenol, BHT) is a potent antioxidant that has a broad spectrum of pharmacological activities. At present, only 10% di-tert-butyl-p-cresol-based sterilization liniment produced in the industry is injected into the bladder for patients with bladder cancer and cystitis. Studies on oral dosage forms resulted in poor gastrointestinal absorption of 0.3 grams of di-tert-butyl-p-cresol tablets and lozenges, better absorption of the oily solution than the tablets, but oily solutions with bitter taste and nausea , Vomiting and diarrhea, so the author made single-coacervation microcapsules, the process is as follows: The di-tert-butyl-p-cresol was dissolved in 20% oil solution of sunflower oil at 20 ℃ under stirring; separately prepared 10% gelatin aqueous solution and 20% sodium sulfate solution. first