论文部分内容阅读
长效避孕药作为计划生育措施在发展中国家倍受欢迎。1月1针的避孕针具有高效和低副反应的优点。近年来采用孕激素-雌激素复合的避孕针,主要通过抑制排卵而达到避孕。现发展一种炔诺酮(NET)10mg+炔雌甲醚(ME)1mg微晶悬浮液的避孕针(以ME代替炔雌醇EE-2),作者对此避孕针的药代动力学和用药期间卵巢功能进行了研究。研究包括8例健康妇女,23.5±3.0岁,参加研究前至少3个周期月经规则(30±2天),6个月内未用过甾体药物,距末次妊娠12个月以上。研究前详细询问病史和进行全身体格检查。研究期间所有对象均用屏障法避孕。每例于月经第5天肌
Long-acting contraceptives are gaining popularity as a family planning measure in developing countries. January 1 needles have the advantages of high efficiency and low side effects. In recent years, the use of progesterone - estrogen compound contraception, mainly through the inhibition of ovulation and achieve contraception. Now the development of a contraceptive needle (ME instead of ethinylestradiol EE-2) suspension of 10 mg of norethindrone (NET) and 1 mg of ethinyl estradiol (ME), the authors of this contraceptive pharmacokinetics and medication Ovarian function during the study. The study included 8 healthy women, 23.5 ± 3.0 years old, with at least 3 cycles of menstruation (30 ± 2 days) before the study, no steroid medication within 6 months, and 12 months or more from the last pregnancy. Before the study asked in detail the history and physical examination. All subjects contraceptive using barrier method during the study. Each case in the first 5 days of menstrual muscle