论文部分内容阅读
目的 探讨乳腺癌与乳腺良性病变的关系。方法 对 5 0例乳腺癌及 5 0例乳腺良性病变标本 ,作全乳腺大切片 ,行病理学观察及癌胚抗原 (CEA)、c -erbB - 2基因、p5 3基因表达的多项指标检测研究。结果 5 0例乳腺癌大切片病理观察显示 ,乳腺导管上皮增生及乳头状瘤病与癌有移行关系。免疫组化检测结果显示 :正常乳腺各项检测均为阴性 ;乳腺良性病变的CEA、c -erbB - 2、p5 3基因阳性表达率较低 ;而乳腺癌组织的CEA、c -erbB -2、p5 3基因的阳性表达率较高。重度乳腺导管上皮不典型增生及重度乳头状瘤病上述指标的阳性表达率与乳腺导管内癌相近。结论 乳腺导管上皮增生及乳头状瘤病与乳腺癌有显著相关性 ,其他乳腺良性病变与乳腺癌无相关性
Objective To investigate the relationship between breast cancer and benign breast lesions. Methods A total breast mass was taken from 50 breast cancer specimens and 50 benign breast lesions. Pathological examination and detection of CEA, c-erbB-2 and p53 genes the study. Results The pathological observation of 50 cases of large breast cancer showed that the ductal hyperplasia and papillomatosis of the breast had a transitional relationship with cancer. The results of immunohistochemistry showed that all the normal mammary glands were detected negatively; the positive expression rates of CEA, c-erbB-2, and p53 genes in benign breast lesions were low; while those of breast cancer were CEA, c-erbB-2. The positive rate of p53 gene expression is higher. The positive expression rate of the above indicators of severe ductal epithelial dysplasia and severe papillomatosis was similar to that of intraductal carcinoma of the breast. Conclusion Breast duct epithelial hyperplasia and papillomatosis have significant correlation with breast cancer. Other benign breast lesions have no correlation with breast cancer.