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为了解甘草甜素对慢性活动性肝炎（ＣＡＨ）患者外周血单个核细胞（ＰＢＭＣ）产生的肿瘤坏死因子－α（ＴＮＦ－α）、白介素－６（ＩＬ－６）的影响，用强力宁（主要成分为甘草甜素）对１８例ＣＡＨ患者ＰＢＭＣ产生ＩＬ－６、ＴＮＦ－α的能力进行了研究。结果显示在体外培养条件下，强力宁可使ＰＢＭＣ产生ＩＬ－６、ＴＮＦ－α的能力减弱；而且ＰＢＭＣ产生ＩＬ－６、ＴＮＦ－α的能力降至最低（接近正常）时所需的剂量在ＣＡＨ活动期明显低于稳定期（Ｐ＜０．０１）。提示用强力宁治疗ＣＡＨ时应根据不同病程调节剂量。研究尚发现强力宁可能具有诱生ＰＢＭＣ膜产生可溶性ＩＬ－６受体的作用，从而中和了培养上清液中的ＩＬ－６。上述结果可部分解释其治疗ＣＡＨ的机理。
To investigate the effect of glycyrrhizin on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) produced by peripheral blood mononuclear cells (PBMCs) in patients with chronic active hepatitis (CAH) The main component of glycyrrhizin) of 18 cases of CAH PBMC IL-6, TNF-α production capacity were studied. The results showed that in vitro culture conditions, the strong rather the ability of PBMC to produce IL-6, TNF-α weakened; and PBMC IL-6, TNF-α production capacity to a minimum (near normal) required dose CAH Active period was significantly lower than the stable period (P <0.01). Tip with strong Ning treatment of CAH should be based on different duration of dose adjustment. The study also found that the strong rather likely to induce PBMC membrane production of soluble IL-6 receptor role, thus neutralizing the culture supernatant of IL-6. The above results may partly explain the mechanism of CAH treatment.