Ruthenium catalyzed amination cyclization of 1,2,4-butanetriol with primary amines:A borrowing hydro

• 作 者: Qing-Song Xu Chen Li Yong Xu Defeng Xu Mei-Hua Shen Hua-Dong Xu
• 机 构: School of Pharmaceutical Engineering&Life Science, Changzhou University, Changzhou 213164, China
• 出 处: 中国化学快报（英文版）
• 发表日期: 2020年1期
• 关键词: Amination cyclization N-Alkylation 1 2 4-Butanetriol 3-Pyrrolidinol Borrowing hy

A ruthenium based catalytic system ([Ru(p-cymene)Cl2]2/XantPhos with substoichiometric Cs2CO3) has been established to effectively achieve the first direct amination cyclization of 1,2,4-butanetriol with primary aromatic amines. The product of this sustainable hydrogen autotransfer process is valuable N-aryl-3-pyrrolidinol.