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目的:观察通腑益气活血法在预防直肠癌全直肠系膜切除术(TME)后吻合口漏及降低其危险因素的作用。方法:将58例直肠癌TME术后患者随机分为2组,对照组除常规基础治疗外不予特殊处理,治疗组在对照组的基础上予通腑益气活血中药雾化、口服及灌洗治疗;观察2组术后吻合口漏发生率,术后血白介素-10(IL-10),C-反应蛋白(CRP)及肿瘤坏死因子(TNF)变化情况。结果:治疗第3、7天2组血IL-10、CRP、TNF分别比较,差异均有显著性意义(P<0.05);治疗组吻合口漏发生率低于对照组,但差异无显著性意义(P>0.05)。结论:通腑益气活血法能降低直肠癌TME术后吻合口漏发生的危险因素,从而预防吻合口漏的发生。
Objective: To observe the effect of Tongfu Yiqihuoxue method in preventing anastomotic leakage and reducing its risk factors after total mesorectal excision (TME) of rectal cancer. Methods: Fifty-eight patients with TME after rectal cancer were randomly divided into two groups. The control group received no special treatment except for routine basic treatment. The treatment group was given Tongfu Yiqi Huoxue Chinese medicine atomization, oral and irrigation on the basis of the control group The incidences of anastomotic leakage and the changes of IL-10, C-reactive protein (CRP) and tumor necrosis factor (TNF) in the two groups were observed. Results: The levels of IL-10, CRP and TNF in the two groups on the 3rd and 7th day after treatment were significantly different (P <0.05). The incidence of anastomotic leakage in the treatment group was lower than that in the control group, but the difference was not significant Significance (P> 0.05). Conclusion: Tongfu Yiqi Huoxue Decoction can reduce the risk factors of anastomotic leakage after TME of rectal cancer and thus prevent the occurrence of anastomotic leakage.