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目的了解河南省某镇人群丙型肝炎病毒(HCV)感染现状。方法采用分层整群抽样的方法,在镇上按东、西、南、北、中地理位置分别确定SL村、MM村、TT村、MN村、PL村5个行政村为调查村,然后对抽中的村中年龄为1岁以上人全部采集血清标本进行调查。血清标本采取两次ELISA法(初筛用丽珠试剂、复筛用万泰试剂)筛查,结果呈阳性者进行核酸NAT试验。结果本次共调查5152人,人群抗-HCV阳性率为2.21%(95%CI:2.17%~2.25%),HCV-RNA阳性率为1.22%(95%CI:1.27%~1.33%)。男性和女性抗-HCV阳性率分别为1.64%、2.64%;HCV-RNA阳性率分别为0.82%、1.52%。SL村、MM村、TT村、MN村、PL村人群抗-HCV阳性率分别为8.05%、1.57%、1.08%,0.53%、0.31%;HCV-RNA阳性率分别为4.60%、0.70%、0.54%、0.44%、0.10%。5个被调查村抗-HCV阳性率和HCV-RNA阳性率相比差别均有统计学意义,其中SL村最高。肌肉注射、静脉推注、输血、手术/窥镜因素与HCV感染有统计学意义。结论 SL村丙肝疫情明显高于周边村,也明显高于全省丙肝的发病水平,该镇的SL村存在促进丙肝疫情传播的危险因素。
Objective To understand the status of hepatitis C virus (HCV) infection in a town of Henan Province. Methods The stratified cluster sampling method was used to determine the 5 administrative villages of SL, MM, TT, MN and PL in the town according to the geographical locations of East, West, South, North and Middle, and then Serious samples collected from all over 1-year-olds in the village were investigated. Serum samples taken two ELISA (initial screening with beads reagent, re-screening with Wantai reagent) screening, the results were positive for nucleic acid NAT test. Results A total of 5152 subjects were investigated. The positive rate of anti-HCV was 2.21% (95% CI: 2.17% -2.25%) and the positive rate of HCV-RNA was 1.22% (95% CI: 1.27% -1.33%). The positive rates of anti-HCV in males and females were 1.64% and 2.64%, respectively. The positive rates of HCV-RNA were 0.82% and 1.52% respectively. The positive rates of anti-HCV in SL, MM, TT, MN and PL villages were 8.05%, 1.57%, 1.08%, 0.53% and 0.31% respectively. The positive rates of HCV RNA were 4.60%, 0.70% 0.54%, 0.44%, 0.10%. The difference between the positive rates of anti-HCV and the positive rates of HCV-RNA in the 5 investigated villages was statistically significant, of which SL village was the highest. Intramuscular injection, intravenous injection, blood transfusion, surgical / endoscopic factors and HCV infection were statistically significant. Conclusion The incidence of hepatitis C in SL village was significantly higher than that in the surrounding villages and significantly higher than that in the whole province. There was a risk factor for the transmission of hepatitis C in SL village.