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应用 Coulter DEL SA4 4 0 zeta电位仪测定一水草酸钙晶体表面的 zeta电位 ,研究高浓度草酸 ( 0 .2 mmol· L-1、 0 .4 mmol· L-1)对古糖酯 ( G872 )与一水草酸钙晶体粘附作用的影响 ;并应用 [3H]G872研究高浓度草酸下 G872在一水草酸钙晶体表面的粘附变化。结果表明高草酸下晶体表面的 zeta电位负值自 2 4 .5m V降低至2 0 .6m V,晶体表面的放射强度显著低于空白对照组 ( P<0 .0 5、P<0 .0 1) ,提示高草酸下只有较少的大分子聚阴离子大分子抑制物 (如 G872 )粘附到晶体表面 ,从而解释了高草酸降低尿路结石症大分子抑制物抑制活性的原因
The zeta potential on the surface of calcium oxalate monohydrate crystals was measured using a Coulter DEL SA4 4 0 zeta potential analyzer to study the high concentration of oxalic acid (0.2 mmol·L-1, 0.4 mmol·L-1) vs. paleose esters (G872) The effect of adhesion with calcium oxalate crystals; and the application of [3H]G872 to study the adhesion of G872 under high concentration of oxalic acid on the surface of calcium oxalate crystals. The results showed that the negative zeta potential on the surface of the crystals with high oxalic acid decreased from 2 4 .5mV to 2 0. 6m V. The intensity of the crystal surface was significantly lower than that of the control group (P<0.05, P<0. 0. 1) , suggesting that only small macromolecular polyanionic macromolecule inhibitors (such as G872) adhere to the crystal surface under high oxalic acid, thus explaining the reason why high oxalic acid reduces inhibitory activity of macromolecular inhibitors of urolithiasis