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6例患儿给予单剂(50mg/kg)头孢哌酮静脉注射,测得主要药动学参数为:k=0.68h (?)、t_(1/2)=1.08h、Vd=2.73L。20例下呼吸道感染患儿给予头孢哌酮治疗,剂量分别为50mg/(kg·d)(10例,组Ⅰ)和100mg/(kg·d)(10例,组Ⅱ),分2次给药。结果显示组Ⅱ的疗效明显优于组Ⅰ。应用头孢哌酮治疗10d 后,组Ⅰ患儿的血清 GPT、AKP和尿γ-GT 分别较治疗前升高6.3%(P<0.001)、11.1%(P<0.01)和44.9%(P<0.02);组Ⅱ患儿的上述项目分别升高17.2%(P<0.01)、21.4%(P<0.01)和164.3%(P<0.01);两组患儿的血 Cr、BUN 和 PT 均无显著改变。
Six patients were given a single dose (50mg / kg) cefoperazone intravenously. The main pharmacokinetic parameters were as follows: k = 0.68h (?), T 1/2 (1/2) = 1.08h, Vd = 2.73L. Cefoperazone was given to 20 children with lower respiratory tract infection at dose of 50 mg / (kg · d) (10 cases, group Ⅰ) and 100 mg / (kg · d) (10 cases, group Ⅱ) medicine. The results showed that the efficacy of group Ⅱ was significantly better than group Ⅰ. After treatment with cefoperazone for 10 days, the serum GPT, AKP and urinary γ-GT in group Ⅰ were significantly increased by 6.3% (P <0.001), 11.1% (P <0.01) and 44.9% (P <0.02) ). The above items in group Ⅱ children increased by 17.2% (P <0.01), 21.4% (P <0.01) and 164.3% (P <0.01) respectively. There was no significant difference in blood Cr, BUN and PT between two groups change.