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目的:探讨老年人冠脉狭窄程度与超敏C反应蛋白(hs-CRP)及脂蛋白(a()LP(a))水平的关系。方法:分析研究260例年龄>60岁的经行冠脉造影检查明确诊断冠心病的患者的冠脉狭窄程度,以及术前空腹采血测定其hs-CRP及LP(a)的水平。结果:①冠脉病变组(186例)与对照组(76例)比较,冠脉病变组Lp(a)和hs-CRP水平分别为(3.30±4.30)mg/L和(146.30±3.21)mg/L,对照组分别为(1.32±2.32)mg/L和(40.26±2.44)mg/L,二者存在差别(P<0.01),差别有统计学意义。②各个亚组病与对照组比较各亚组(单支病变组、双支病变组、三支病变组)hs-CRP和LP(a)与对照组相比较存在明显差异,单支病变组51例,双支病变组72例,三支病变组63例。单支病变组hs-CRP和Lp(a)水平分别为(2.11±1.31)mg/L和(41.58±2.32)mg/L,双支病变组分别为(2.97±2.11)mg/L和(47.12±1.21)mg/L,三支病变组分别为(3.42±2.16)mg/L和(60.13±3.54)mg/L,P<0.05,差别有统计学意义,且随着病变支数的增加,hs-CRP和LP(a)呈增高趋势。并行单因素相关分析,hs-CRP和LP(a)与冠脉病变支数有正相关关系(P<0.05)。③男性病变组(107例)和女性病变组(79例),男性组hs-CRP和LP(a)水平分别为(1.87±2.11)mg/L和(43.60±2.18)mg/L,女性病变组hs-CRP和LP(a)水平分别为(3.33±1.70)mg/L和(50.77±2.47)mg/L,二者存在差别,P>0.05,差别无统计学意义。结论:老年人冠脉狭窄程度与血清Lp(a)和hs-CRP水平变密切相关,呈正相关,老年男性冠心病患者与女性冠心病患者相比,血清Lp(a)和hs-CRP水平无显著差异。
Objective: To investigate the relationship between the degree of coronary artery stenosis and the levels of hs-CRP and lipoprotein (a () LP (a)) in the elderly. Methods: The coronary stenosis of 260 patients aged> 60 years whose coronary angiography was confirmed by coronary angiography was studied. The levels of hs-CRP and LP (a) were determined by preoperative fasting blood sampling. Results: ① The levels of Lp (a) and hs-CRP in coronary artery disease group were (3.30 ± 4.30) mg / L and (146.30 ± 3.21) mg respectively, compared with control group (186 cases) / L in the control group and (1.32 ± 2.32) mg / L and (40.26 ± 2.44) mg / L respectively in the control group (P <0.01). The difference was statistically significant. (2) Compared with the control group, there were significant differences in hs-CRP and LP (a) between each subgroup and control group (single branch group, double branch group and triple branch group) For example, there were 72 cases of double-vessel disease and 63 cases of three-vessel disease. The levels of hs-CRP and Lp (a) in single vessel disease group were (2.11 ± 1.31) mg / L and (41.58 ± 2.32) mg / L respectively, and those in double vessel disease group were (2.97 ± 2.11) mg / L and ± 1.21) mg / L, and the three lesions were (3.42 ± 2.16) mg / L and (60.13 ± 3.54) mg / L respectively, P <0.05. The difference was statistically significant. hs-CRP and LP (a) showed an increasing trend. Parallel univariate correlation analysis, hs-CRP and LP (a) and coronary lesions have a positive correlation (P <0.05). The levels of hs-CRP and LP (a) were (1.87 ± 2.11) mg / L and (43.60 ± 2.18) mg / L respectively in the male disease group (107 cases) and the female disease group (79 cases) The levels of hs-CRP and LP (a) were (3.33 ± 1.70) mg / L and (50.77 ± 2.47) mg / L, respectively. There was a significant difference between the two groups (P> 0.05). CONCLUSIONS: There is a positive correlation between the degree of coronary stenosis and the levels of serum Lp (a) and hs-CRP in elderly patients. Compared with female patients with CHD, the levels of serum Lp (a) and hs-CRP Significant differences.