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目的研究住院病人感染鲍曼不动杆菌的分布及其耐药性变化,为预防控制和合理使用抗菌药物提供依据。方法通过病人感染标本检测和药敏试验方法,对某医院2010-2012年住院患者送检标本检测结果进行调查与分析。结果调查期间,从住院患者送检标本中共分离出病原菌4 988株,其中鲍曼不动杆菌536株,占10.75%。连续3年病人送检标本鲍曼不动杆菌分离率总体呈上升趋势。鲍曼不动杆菌感染以呼吸道为主,占69.67%。送检标本主要来自该医院神经外科、呼吸科、儿科和心胸外科。鲍曼不动杆菌对多粘菌素B和亚胺培南全部敏感。结论该医院病人送检标本鲍曼不动杆菌平均分离率为10.75%,呈上升趋势,应把药敏试验选择抗菌药物和加强消毒隔离作为主要防控措施。
Objective To study the distribution and drug resistance changes of Acinetobacter baumannii in inpatients, and provide basis for prevention and control and rational use of antimicrobial agents. Methods Through the test of patient’s infection specimen and drug susceptibility testing method, the test results of inpatients from 2010 to 2012 in a hospital were investigated and analyzed. Results During the investigation, a total of 4 988 pathogens were isolated from hospitalized patients, of which 536 Acinetobacter baumannii strains accounted for 10.75%. Acinetobacter baumannii isolates showed an overall upward trend for three consecutive years. Acinetobacter baumannii infection mainly respiratory, accounting for 69.67%. The specimens were mainly from the hospital neurosurgical, respiratory, pediatric and cardiothoracic surgery. Acinetobacter baumannii polymyxin B and imipenem are all sensitive. Conclusion The average isolation rate of Acinetobacter baumannii in this hospital patient is 10.75%, which shows an upward trend. It is suggested that antimicrobial agents should be chosen as drug-susceptibility test and disinfection and isolation should be strengthened as the main prevention and control measures.