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腺病毒可通过其衣壳蛋白与宿主细胞受体的相互作用有效地进入细胞。近年来人们通过深入研究腺病毒进入细胞的机制及感染机体后诱生的免疫应答得知,衣壳蛋白的纤突介导腺病毒与靶细胞的结合,不同血清型的腺病毒与不同细胞的受体结合;机体感染腺病毒后可产生针对衣壳蛋白各组分,如六邻体、五邻体及纤突的抗体。目前已肯定抗六邻体抗体在中和病毒感染、限制腺病毒载体反复使用中的作用,但对抗纤突抗体的作
Adenovirus efficiently enters cells through the interaction of its capsid protein with host cell receptors. In recent years, people through in-depth study of adenovirus into the cell mechanism and the immune response induced after infection of the body that the capsid protein fiber mediated adenovirus and target cell binding, different serotypes of adenovirus and different cells Receptor binding; the body infected with adenovirus can produce capsid protein components, such as hexon, penton and fiber sudden antibody. At present it has been affirmed that anti-hexon antibody neutralizes viral infection and limits the repeated use of adenoviral vector, but the anti-fibrin antibody