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目的探讨ANA、SSA、SSB检测对干燥综合征诊断中的临床意义。方法选取本院2005年1月至2009年10月门诊或住院干燥综合征患者68例。同期诊断的非干燥综合征患者70例为对照组,进行检测ANA、SSA、SSB,观察阳性率并进行比较分析。68例干燥综合征患者ANA阳性47例占69.11%;SSA阳性57例占83.82%;SSB阳性27例占39.70%;SSA/SSB阳性11例占16.17%.两组经统计学比较:ANA检测阳性率比较(P>0.05)无显著差异性。两组SSA、SSB、SSA/SSB检测阳性率比较P<0.05有显著差异性。结论干燥综合征检测项目中ANA缺乏特异性,是许多结缔组织病都可以表达的,SSA、SSB、SSA/SSB检测对干燥综合征具有较强的特异性,在其他结缔组织病表达较少,对诊断干燥综合征更具有指导性。
Objective To investigate the clinical significance of ANA, SSA and SSB in the diagnosis of Sjogren’s syndrome. Methods From January 2005 to October 2009 in our hospital outpatient or hospitalized patients with syndrome of 68 cases. In the same period, 70 patients with non-Sjogren’s syndrome were selected as the control group. The detection rate of ANA, SSA and SSB were observed and compared. The positive rate of ANA in 47 cases was 69.11% in 68 cases of Sjogren’s syndrome, 83.82% in 57 cases of SSA positive, 27 cases of SSB positive in 27 cases and 16.17% in SSB positive group, 27 cases in SSB positive group Rate comparison (P> 0.05) no significant difference. The positive rates of SSA, SSB and SSA / SSB in two groups were significantly different from those of P <0.05. Conclusions ANA deficiency in Sjogren’s syndrome test items can be expressed in many connective tissue diseases. SSA, SSB and SSA / SSB tests have strong specificity for Sjogren’s syndrome and less for other connective tissue diseases. On the diagnosis of Sjogren’s syndrome is more instructive.