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天津医药工业研究所、天津职业病防治院,为了寻找一种防治矽肺的高效低毒的铝盐,观察了山梨醇铝对实验性矽肺的治疗作用。实验动物系采用健康的雄性大鼠12只(治疗组与对照组各6只),在乙醚麻醉下气管内注入石英粉尘1毫升(内含石英粉尘50毫克)。治疗组染尘后一周开始投药,每只动物每次给5%山梨醇铝生理盐水溶液1毫升腹腔注射,一周三次,连续给药两个月。实验终末,杀死动物,对两肺及主要实质脏器(心、肝、脾、肾、肾上腺)进行病理形态学检查,并对肺干重及全
The Tianjin Institute of Pharmaceutical Industry and Tianjin Occupational Disease Prevention and Treatment Center looked for the therapeutic effect of aluminum sorbitol on experimental silicosis in order to find a highly effective and low toxic aluminum salt for preventing silicosis. In the experimental animal group, 12 healthy male rats (6 in the treatment group and 6 in the control group) were used. Under ether anesthesia, 1 ml of quartz dust (containing 50 mg of quartz dust) was injected into the trachea. One week after the dust treatment in the treatment group, the animals were dosed, and each animal was intraperitoneally administered with 1 ml of 5% sodium sorbitol saline solution intraperitoneally three times a week for two months. At the end of the experiment, the animals were killed and pathomorphological examinations were performed on the two lungs and major parenchymal organs (heart, liver, spleen, kidney, adrenal glands), and the lung dry weight and