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目的研究Survivin在非小细胞肺癌(NSCLC)支气管切缘和肺癌组织中的表达情况及与肺癌局部复发和预后的关系。方法应用免疫组织化学技术(二步法)检测47例NSCLC和10例肺部良性疾病手术切除标本的支气管切缘(切缘病理无癌残留)、病灶组织和正常肺组织中的Survivin表达,并随访了解术后切缘癌复发与癌复发转移情况。结果12例(25.53%)肺癌支气管切缘和28例(59.57%)肺癌组织Survivin阳性表达,正常肺组织和良性病变肺组织Survivin表达均阴性。支气管切缘Survivin阳性组术后随访6￣16月4,例(33.33%)发生支气管残端癌复发,而Survivin阴性组术后无残端癌复发。手术切缘Survivn阳性组与阴性组的5年生存率分别为25.0%和54.29%,肺癌组织中Survivin阳性组与阴性组的5年生存率分别为32.14%和68.42%,差异有统计学意义(P<0.05)。结论手术切缘Survivin表达阳性可早期预测部分非小细胞肺癌的术后残端癌复发,肺癌组织Survivin阳性表达提示患者预后不良。
Objective To investigate the expression of Survivin in non-small cell lung cancer (NSCLC) bronchial margins and lung cancer and its relationship with local recurrence and prognosis of lung cancer. Methods Immunohistochemical technique (two-step method) was used to detect the expression of Survivin in 47 NSCLC and 10 cases of benign lung diseases, which were surgically resected in the bronchotomy (no marginal pathology), lesions and normal lung tissues Follow-up to understand the recurrence of cancer and cancer recurrence and metastasis. Results Survivin was positively expressed in 12 cases (25.53%) of lung cancer and 28 cases (59.57%) of lung cancer tissues, while the expression of Survivin in normal lung tissue and benign lesion lung tissue was negative. Bronchoscopic Survivin positive group were followed up for 6 to 16 months 4 cases (33.33%) recurrence of bronchial stump cancer, and Survivin negative group no recurrence of stump cancer. The 5-year survival rates of Survivn positive and negative surgical margins were 25.0% and 54.29% respectively. The 5-year survival rates of Survivin positive and negative lung cancer groups were 32.14% and 68.42%, respectively, with significant difference (P < P <0.05). Conclusion The positive Survivin expression at the operative margin can predict the recurrence of stump cancer in some non-small cell lung cancer patients at the early stage. The positive expression of Survivin in lung cancer suggests that the prognosis is poor.