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Diversity-oriented synthesis(DOS) has been widely applied in the generation of a large collection of highly functionalized molecules with diverse chemical skeletons.Herein,we report the diversity-oriented synthesis of a series of structurally diverse bicyclic substrates via an efficient tandem conjugate addition/aldol process followed by ring-closing metathesis(RCM).This approach allows us to efficiently prepare a number of structurally complex molecules for the further chemical biology studies.
Diversity-oriented synthesis (DOS) has been widely applied in the generation of a large collection of highly functionalized molecules with diverse chemical skeletons. Heinin, we report the diversity-oriented synthesis of a series of structurally-diverse bicyclic substrates via an efficient tandem conjugate addition / aldol process followed by ring-closing metathesis (RCM) .This approach allows us to efficiently prepare a number of structurally complex molecules for the further chemical biology studies.