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了解扬州地区手足口病（HFMD）流行现状及病原学特征，为该地区HFMD防控提供依据。以2015年1月至2019年12月扬州市6家哨点医院常规监测的HFMD病例为研究对象，对病例资料进行描述性流行病学分析，采用实时荧光定量PCR方法对病例标本进行肠道病毒核酸检测，并进行病原学特征分析。2015至2019年扬州市累计检测HFMD临床标本2 129份，共检出肠道病毒阳性1 151份（总阳性率为54.06%），包括EV71型148份（6.95%）、CA16型382份（17.94%）和其他型肠道病毒（其他EV）621份（29.17%）。不同年份（χ2=99.28， n P<0.05）、不同月份（χ2=92.09，n P<0.05）、不同区县（χ2=71.39，n P<0.05）的阳性率差异均有统计学意义。各种型别优势毒株交替流行，4至9月份为发病高峰期（720份，62.55%），男性病例多于女性，男女性别比为1.58∶1，病例以≤6岁儿童为主（971份，84.36%）。2015至2019年扬州地区HFMD流行呈现明显的季节性、地域性和人群分布特征，提示应继续加强监测，尤其重视高发季节对重点人群的防控，并关注由其他EV引起的HFMD。n “,”To understand the prevalence and etiological characteristics of hand, foot and mouth disease(HFMD) in Yangzhou, so as to provide scientific basis for prevention and control of HFMD. HFMD cases from six sentinel hospitals in Yangzhou from January 2015 to December 2019 were taken as the subject of study. The epidemiological data of HFMD were analyzed by descriptive epidemiology method, the enterovirus were detected using RT-PCR method and the etiological characteristics were analyzed. The data were collected by Excel 2007 and statistically analyzed by SPSS22.0 software. A total of 1 151 positive cases were detected from all 2 129 HFMD clinical specimens collected in Yangzhou from 2015 to 2019, with a total positive rate of 54.06%, including 148 cases of EV71(6.95%), 382 cases of CA16(17.94%) and 621 cases of other enterovirus(29.17%). The difference of positive rate in different years(n χ2=99.28, n P<0.05), different months(n χ2=92.09, n P<0.05) and different districts(n χ2=71.39, n P<0.05)was statistically significant. Each subtype of enterovirus showed alternating prevalence in different years. The peak period of detection rate was from April to September (720 cases, 62.55%). The reported incidence for males was higher than females, with the male-female ratio of 1.58∶1 and children under six (971 cases, 84.36%) as the major attacked population. There were obvious seasonal, regional and population characteristics of HFMD in Yangzhou City from 2015 to 2019. It reminds us that surveillance of HFMD should be continually implemented, more attention should be paid to the prevention and control of key population in high-risk seasons, and the booming HFMD cases caused by other enterovirus should be emphasized especially.n