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目的:介绍药物代谢酶和药物转运体基因多态性与儿童急性淋巴细胞白血病化疗关系的研究进展。方法:查阅相关文献,并对其进行分析、归纳、总结。结果与结论:药物代谢酶和药物转运体基因多态性可以影响儿童急性淋巴细胞白血病化疗药物的药动学和药效学参数,与治疗药物的效应及毒副作用之间存在一定的相关性,但离将这些多态性位点的基因型作为儿童急性淋巴细胞白血病化疗决策的依据尚有一定距离。
Objective: To introduce the research progress of the relationship between drug metabolism enzyme and drug transporter gene polymorphism and chemotherapy of childhood acute lymphoblastic leukemia. Methods: consult the relevant literature, and analyze, summarize, summarize. RESULTS AND CONCLUSION: The polymorphisms of drug metabolizing enzymes and drug transporters could affect the pharmacokinetic and pharmacodynamic parameters of chemotherapeutic drugs in children with acute lymphoblastic leukemia, and have some correlations with the therapeutic effects and side effects. However, there is a certain distance from using the genotypes of these polymorphic loci as the basis for the decision-making of chemotherapy for childhood acute lymphoblastic leukemia.