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目的 观察慢性肝炎 (CH)高压氧 (HBO)治疗前后患者的体液免疫功能和肝组织中 HB-s Ag、HBc Ag的变化。方法 用单人纯氧舱治疗 (0 .2 5 MPa,1.5 h/ d,10 d/ course,6 courses) 6 0例 CH,用 Array TM Protein System Array16 0测定治疗前后静脉血α-白蛋白、γ-球蛋白 ,Ig A、Ig G、Ig M,补体C1 、C4 ;肝穿刺活检 ,SP法检测肝组织中 HBs Ag、HBc Ag。结果 HBO治疗后 CH患者静脉血γ-球蛋白、Ig A、Ig G、Ig M、补体 C1 、C4 明显降低 ,α-白蛋白明显升高 ,治疗前后差异显著 (P<0 .0 5 ) ;CH患者肝组织中 HBs Ag、HBc Ag变化不明显 ,治疗前后差异不显著 (P>0 .0 5 )。结论 HBO治疗 CH,可降低患者的体液免疫反应 ,对 CH肝组织中 HBs Ag、HBc Ag抑制作用不明显。
Objective To observe the changes of humoral immune function and HBsAg, HBc Ag in liver tissue of patients with chronic hepatitis (CH) before and after HBO treatment. Methods 60 cases of CH (0. 25 MPa, 1.5 h / d, 10 d / course, 6 courses) were treated with single pure oxygen chamber. The contents of α-albumin, γ-globulin, Ig A, Ig G, Ig M, complement C1, C4; liver biopsy, SP method detection of liver tissue HBsAg, HBcAg. Results After treatment with HBO, the levels of γ-globulin, Ig A, Ig G, Ig M, complement C1 and C4 in patients with CH were significantly decreased and α-albumin was significantly increased, with significant difference before and after treatment (P <0.05); There was no obvious change of HBs Ag and HBc Ag in the liver of patients with CH, but the difference was not significant before and after treatment (P> 0.05). Conclusion The treatment of CH with HBO can reduce the humoral immune response in patients with CH and liver HBsAg Ag, HBc Ag inhibition was not obvious.