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目前已经从啮齿类动物及人的脑和脊髓内分离出神经干细胞。生长因子FGF - 2和EGF是神经干细胞增殖的主要分裂源 ,而干细胞分化则受其起源、培养条件、各种细胞因子等调控 ,实验发现可以用后天信号操纵神经干细胞的分化以期获得目的神经生化表型。近来在成年人脑中发现干细胞并且成功建立了永生化细胞系 ,极大地鼓舞了人们设想内源性细胞移植及发展新的有前途的基因治疗载体 ,为神经组织的结构和功能重建提供了新的手段 ,具有广阔的应用前景。
Neural stem cells have now been isolated from rodents and human brains and spinal cords. The growth factors FGF - 2 and EGF are the main sources of neural stem cell proliferation. However, stem cell differentiation is regulated by its origin, culture conditions and various cytokines. It is found that neural stem cells can be manipulated by acquired signals to acquire the target neurobiochemical Phenotype. The recent discovery of stem cells in adult brains and the successful establishment of immortalized cell lines have greatly encouraged people to envision endogenous cell transplantation and to develop new promising gene therapy vectors that provide new structures and functional reconstructions of neural tissues The means that has broad application prospects.