Graphene nanopores toward DNA sequencing: a review of experimental aspects

• 作 者: Wei Chen Guo-Chang Liu Jun Ouyang Meng-Juan Gao Bo Liu Yuan-Di Zhao
• 机 构: Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hube
• 出 处: Science China(Chemistry)
• 发表日期: 2017年06期
• 关键词: sequencing DNA translocation fabrication throughput nuclei toward addressed draw

Nanopores for DNA sequencing have drawn much attention due to their potentials to achieve amplification-free, low-cost, and high-throughput analysis of nuclei acids. The material configuration and fabrication of the nanopore has become one important consideration in the nanopore based DNA sequencing research. Among various materials, the newly emerged graphene has brought more opportunities to the development of sequencing technology because of its unique structures and properties. This review mainly focuses on the experimental aspects of graphene nanopore research including the nanopore fabrication methods and processes. Meanwhile, the challenges in the present graphene nanopore research including hydrophobicity, translocation velocity and noise are also addressed and discussed.

Nanopores for DNA sequencing have drawn much attention due to their potentials to achieve amplification-free, low-cost, and high-throughput analysis of nuclei acids. The material configuration and fabrication of the nanopore has become one important consideration in the nanopore based DNA sequencing research. Among various materials, the newly emerged graphene has brought more opportunities to the new development graphene has brought more opportunities to the development of sequencing technology because of its unique structures and properties. This review focuses on the experimental aspects of graphene nanopore research including the nanopore fabrication methods and processes. Meanwhile, the challenges in the present graphene nanopore research including hydrophobicity, translocation velocity and noise are also addressed and discussed.