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Epostane〔(4α,5α,17β)-4,5-桥氧-3,17-二羟-4,17-二甲基雄甾-2-烯-2-腈,win32729〕有抑制黄体作用,在体外,它可竞争性抑制3B-羟甾体脱氢酶活性,后者能促使娠烯醇酮转化为孕酮。本文报告了Epostane对正常和注射hCG的恒河猴黄体期孕酮(P)的影响。研究采用雌性成年恒河猴。Epostane对正常黄体期P水平的影响,使用22只行经的恒河猴,用药前周期为26～30天,用药前3个周期中至少一个周期第16、17、18天血P≥2.0ng/ml。从周期第18天起6只猴每天用赋形剂,6只猴每天给Epostane25mg,5只猴每天给Epostane 50mg,另5只猴
Epostane [(4α, 5α, 17β) -4,5-epoxy-3,17-dihydroxy-4,17-dimethylandrost-2-ene-2-carbonitrile, win32729] In vitro, it competitively inhibits 3B-hydroxysteroid dehydrogenase activity, which can promote the conversion of pregnenolone to progesterone. This article reports the effect of Epostane on rhesus monkey progesterone (P) in normal and hCG injected. Study using female adult rhesus monkeys. Epostane on the normal luteal phase P levels, the use of 22 Rhesus macaques, pre-treatment period of 26 to 30 days, at least one of the three cycles before treatment on the first 16, 17, 18 days blood P ≥ 2.0ng / ml. From the 18th day of the cycle, 6 monkeys were given daily excipients, 6 monkeys given Epostane 25mg daily, 5 monkeys given Epostane 50mg daily and the other 5 monkeys